Focal segmental glomerular sclerosis (FSGS) is a common primary glomerular disease .The histopathological features are that the glomerular segmental is scar with or without foam cell formation and adhesion in glomerular capillary.Focal refers to only a part of glomerulus is involvement (involvement part< 50%).Segmental refers to the part of the glomerulus leaflet is involvement;Ball hydrogenated refers to the entire glomerular periodic hyaline changes or scarring.
cause
Focal segmental glomerular sclerosis have a variety of pathogenic factors. Such as poisoning, humoral immunity and hemodynamic changing, all can cause the damage of capillary wall, making the macromolecular protein appear and retention. Immunoglobulin deposition combing with C1q and C3 lead to podocyte degeneration and away from the basement membrane phase.
Complications
Infection is a common complication of nephrotic syndrome
Thrombosis, embolism complications
Acute renal failure.
moreThe disease often occur in children and adolescents,and men is more than women getting the disease.For a few patients, before the disease onset , their upper respiratory tract have gotten infection or allergic reaction.The most common clinical symptoms of it is nephrotic syndrome.
Foamy urine
Blood in urine
Edema
High blood pressure
High blood cholesterol level
Poor appetite
Nausea and vomiting
Fatigue
moreThe disease is easily to handle with the timely and effective treatment in the early stage. Or the disease is chronic progressive process, eventually chronic renal failure would appear..
Treatment principle of FSGS
(1) effective symptomatic treatment including anticoagulant, resisting thrombosis, lower blood pressure, fall hematic fat, reduce proteinuria, maintenance and support of nutrition therapy;
(2) protect renal function: prevent or delay the renal damage. Slow down disease progression,
(3) prevention and treatment of complications, including infection, thromboembolic complications, water electrolyte and acid-base metabolism abnormality and the adverse reactions of drug treatment, etc.;
Micro Chinese Medicine Osmotherapy
Expansion of blood vessels
All kidney disease patients, as a result of inflammatory mediators and all kinds of oxidative stress in the blood, will finally get into damage of blood vessels at all levels which means it will inevitably lead to the circulation obstacle and chemia, hypoxia of micro circulation system, damaging kidney inherent cells. The composition of Chinese medicine have function in expansion of blood vessel. And the practice has proved that traditional Chinese medicine (TCM) in many pharmaceutical ingredients is faster than western medicine. So, if have a good use of TCM, expanding blood vessel function is no doubt, and have obvious effect in proteinuria reduction.
The anti-inflammatory
A large number of inflammatory mediators must appear in the blood circulation with the emergence of nephritis. The anti-inflammatory effects of Chinese traditional medicine is obvious, especially in the treatment of chronic inflammation.
Anticoagulation, prevent thrombosis
Appearance of inflammatory lesions will inevitably lead to the more activity of platelet, which would cause normal blood viscosity have the direction of blood coagulation. And blood coagulation factor increasing will gradually form thrombus, and thrombosis in the blood are formed at different levels. The unique feature of the Chinese medicine is activating blood circulation. At the same time,it also showed a strong role on the anti-inflammatory treatment.
Degradation of extracellular matrix
From the perspective of western medicine, the invasion of the harmful substances lead to hyperplasia of the renal inherent extracellular matrix. Treatment practice found that some active substances in traditional Chinese medicine (TCM) show strong role in promoting activity of lysosomal which could secret some enzymes decomposing extracellular matrix. Thus it can degrade the excessive increased extracellular matrix.
moreA healthy lifestyle is necessary for patient to prevent the disease developing into more serious stage.
Diet
Low salt intake
More salt intake would make the edema condition more serious.
Low protein intake
Low protein intake could decrease the urea in blood and decrease the kidney burden.So you should eating less foods such as milk, cheese, yogurt,meat and so on.
High quality protein
High quality protein is necessary for the patient daily activities. Less in quantity, But more in quality. Foods like lean meat, fish, egg white ect. are OK.
low-potassium
High potassium foods include banana, date, potato, spinach, mushroom, etc. Therefore, these foods should be avoided.
low-phosphorus
Phosphorous is high in foods like animal liver, yolk, tea, peanut, walnut, sesame, etc. Therefore, these foods should be avoided.
Daily life
Proper exercise
Stop drinking and smoking
Have a good rest
Keep a good mood
more
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